![]() 2 17 18 In addition, it would appear that adjunctive aripiprazole is one of the safest strategies to improve hyperprolactinaemia induced by APs. 7 12–14Įmerging evidence has found that aripiprazole, a partial agonist of dopamine D2 receptors, 15 16 could effectively reduce prolactin level and increase the rate of prolactin normalisation, and even improve prolactin-related symptoms in patients with AP-related hyperprolactinaemia. There have been several treatment strategies recommended to prevent or alleviate hyperprolactinaemia in clinical practice although some remain controversial because (1) the use of the lowest effective AP dose may increase the risk of relapse during maintenance treatments 5 (2) switching to other APs with a lower risk of hyperprolactinaemia could be associated with some other adverse effects, such as sedation and metabolic syndrome 6 (3) adding a dopamine agonist, such as cabergoline, may result in abnormal involuntary movements and aggravated psychosis 7 8 (4) the use of metformin, which may bring benefits to some hyperprolactinaemic patients, 9 10 may be associated with gastrointestinal reactions 11 and (5) the evidence for the use of paeoniae–glycyrrhiza decoction, a herbal medicine formula consisting of paeonia and glycyrrhiza radices (Shaoyao-Gancao-Tang in Chinese and Shakuyaku-Kanzo-To in Japanese, TJ-68), is still lacking. 1 2 With the rates up to 86%, 3 it is closely related to the dopamine D2 receptor gene Taq1A genotype. ![]() Hyperprolactinaemia caused by antipsychotics (APs) is a serious and unwanted adverse effect in patients with schizophrenia. Correspondence to Dr Wei Zheng zhengwei0702umac.mo.10 Center for Cognition and Brain Sciences, University of Macau, Macao SAR, China.9 Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China.8 Shangrao Fifth People's Hospital, Shangrao, China. ![]() 7 Chongqing Jiangbei Mental Health Center, Chongqing, China.6 Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.5 Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Western Australia, Australia.4 University of Notre Dame Australia, Fremantle, Western Australia, Australia.3 School of Medicine, Xiamen University, Xiamen, China.2 Shenzhen Traditional Chinese Medicine, Shenzhen, China.1 The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, China.
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